Personal profile:
D., Professor, PhD supervisor, recipient of the Outstanding Youth Fund of the National Foundation of China, and the New Century Outstanding Talent of the Ministry of Education. He is mainly engaged in the research of toxic effects and molecular mechanism of environmental pollutants. He has published more than 100 SCI papers, including Proc Natl Acad Sci USA. He was awarded the Outstanding Youth Fund of National Natural Science Foundation of China, the New Century Outstanding Talents Program of the Ministry of Education, and the title of "Search for Young Science Stars". He is the young director of the Professional Committee on Biological Effects of Reactive Oxygen Species in China, a member of the Environmental Chemistry Branch of the Chinese Society of Environmental Sciences, and a member of the Youth Committee of the Chinese Society of Toxicology.
Education and work experience:
1997.09-2001.07 Wuhan University, School of Chemical and Molecular Sciences, B.S.
2001.09-2006.10 Wuhan University, School of Chemical and Molecular Sciences, Ph.
2006.10-2008.12 University of Iowa, School of Public Health/Medical School, USA, Postdoctoral appointment
2009.10-2010.03 Senior Visiting Scholar, University of Iowa, College of Medicine, USA
2012.08-2013.02 Senior Visiting Scholar, School of Chemistry, University of Florida, USA
2008.12-2021.05 Southwest University, School of Pharmacy, Professor, PhD Supervisor
2021.05-Present Researcher/PhD Supervisor, Centre for Ecological and Environmental Research, Chinese Academy of Sciences
Major part-time positions：
(1). Young Director of the Chinese Committee on Biological Effects of Reactive Oxygen Species, Senior Member of the Chinese Chemical Society, Full Member of the American Chemical Society and Full Member of the Society For Free Radical Biology & Medicine
(2). He is an expert of the National Science and Technology Foundation, Ministry of Science and Technology, Ministry of Education, Ministry of Personnel and Chongqing Municipality.
(3). Reviewer for international journals such as Chem Res Toxicol, Food Chem Toxicol, Environ Sci Technol, J Hazard Mater, J Appl Toxicol and Free Radical Bio Med
Awards Received：
(1) Ministry of Education New Century Excellent Talent Support Program, 2009
(2) Southwestern University Talent Fund, 2010
(3) Scoups "Search for Young Science Stars", 2012
(4) Outstanding Communist Party Member, Southwest University, 2012
(5) Outstanding Youth Fund of National Foundation of China, 2016
(6) Outstanding Young Scientist Award, Chinese Society of Toxicology, 2020
Research direction of the group:
Research on the toxicological effects and health risks caused by exposure to environmental pollutants.
(1) Toxicological effects and health risks of organic pollutants.
(2) Toxicological effects and health risks of environmental nanomaterials.
The main scientific projects that the group has conducted research on:
(1) Polychlorinated biphenyl quinones (PCBQs) regulate the signaling process of tumor microenvironment promoting metastasis and invasion through reactive oxygen species mechanism, 2020-01--2023-12, Chair
(2) National Natural Science Foundation of China (NSFC-21622704): Environmental Toxicology and Health Effects, 2017.01-2019.12, Chair
(3) National Natural Science Foundation of China (NSFC-21477098): Mechanisms of oxidative stress-related signaling and neurotoxic effects induced by polychlorinated biphenyl quinones and antioxidant intervention, 2015.01-2018.12, Chair
(4) National Natural Science Foundation of China (NSFC-20907037): Searching for the Missing Link in the PCB Metabolic Pathway, 2010.01-2012.12, Supported by
(5) New Century Excellent Talents Support Program of Ministry of Education (NCET-10-0660): 2010.01-2012.12, Chair
(6) The sub-project of the Ministry of Science and Technology (2010ZX09401-306-2-19): Preclinical research on the antitumor drug mercapto cyclophosphamide, 2010.01-2012.12, Chair
(7) Scientific Research Start-up Fund for Returnees to China (2011[508]): Study on the relationship between free radicals and toxicity induced by PCBs and their derivatives, 2011.08-2014.07, Chair
(8) Natural Science Foundation of Chongqing Municipality (CSTC-2009BB5005): Design, Synthesis and Bioactivity of Dual Function Antitumor Activating Precursors, 2009.03-2012.02, Supported by
(9) Central Universities Basic Research Funds Team Project (XDJK2016A004): Antioxidant Strategies to Intervene in Inflammatory Processes, 2016.01-2017.12, Chair
(10) Major Project of Basic Research Funds for Universities (XDJK2014A020): Molecular mechanism and medicinal basis of plant-derived polyphenolic compounds to prevent Alzheimer's disease, 2014.03-2017.02, presided
(11) Key Project of Basic Research Funds of Central Universities (XDJK2010B008): Design and Evaluation of Antibody-Directed Antitumor Pre-drugs Based on Aminopeptidase, 2010.11-2013.10, Chair
(12) SWUB2008077: Small Molecules for Telomerase Inhibition by Covalently Cross-linked G-Tetramers, Southwest University, 2009.01-2011.12, Chair
Recent major representative papers:
[1] Liu, Zixuan, Zhu, Qiushuang, Song, Erqun, Song, Yang. Polybrominated diphenyl ethers quinone exhibits neurotoxicity by inducing DNA damage, cell cycle arrest, apoptosis and p53-driven adaptive response in microglia BV2 cells. TOXICOLOGY[J]. 2021, 457: http://dx.doi.org/10.1016/j.tox.2021.152807.
[2] Bondarenko, Olesja, Mortimer, Monika, Kahru, Anne, Feliu, Neus, Javed, Ibrahim, Kakinen, Aleksandr, Lin, Sijie, Xia, Tian, Song, Yang, Davis, Thomas P, Lynch, Iseult, Parak, Wolfgang J, Leong, David Tai, Ke, Pu Chun, Chen, Chunying, Zhao, Yuliang. Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade. NANO TODAYnull. 2021, 39: http://dx.doi.org/10.1016/j.nantod.2021.101184.
[3] Lv, Xuying, Liu, Zixuan, Xu, Lei, Song, Erqun, Song, Yang. Tetrachlorobenzoquinone exhibits immunotoxicity by inducing neutrophil extracellular traps through a mechanism involving ROS-JNK-NOX2 positive feedback loop. ENVIRONMENTAL POLLUTION[J]. 2021, 268: http://dx.doi.org/10.1016/j.envpol.2020.115921.
[4] Zhu, Qiushuang, Liu, Zixuan, Wang, Yuting, Song, Erqun, Song, Yang. Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 411: http://dx.doi.org/10.1016/j.jhazmat.2020.124958.
[5] Qi Qin, Bingwei Yang, Zixuan Liu, Lei Xu, Erqun Song, Yang Song. Polychlorinated Biphenyl Quinone Induced the Acquisition of Cancer Stem Cells Properties and Epithelial-Mesenchymal Transition through Wnt/β-catenin. Chemosphere. 2021, 263: http://dx.doi.org/10.1016/j.chemosphere.2020.128125.
[6] Liu, Zixuan, Lv, Xuying, Yang, Bingwei, Qin, Qi, Song, Erqun, Song, Yang. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity. CHEMOSPHERE[J]. 2021, 264: http://dx.doi.org/10.1016/j.chemosphere.2020.128413.
[7] Yunxiang Sun, Aleksandr Kakinen, Xulin Wan, Niamh Moriarty, Cameron PJ Hunt, Yuhuan Li, Nicholas Andrikopoulos, Aparna Nandakumar, Thomas P Davis, Clare L Parish, Yang Song, Pu Chun Ke, Feng Ding. Spontaneous formation of β-sheet nano-barrels during the early aggregation of Alzheimer’s amyloid beta. Nano Today. 2021, 38: http://dx.doi.org/10.1016/j.nantod.2021.101125.
[8] Liu, Zixuan, Xia, Xiaomin, Lv, Xuying, Song, Erqun, Song, Yang. Iron-bearing nanoparticles trigger human umbilical vein endothelial cells ferroptotic responses by promoting intracellular iron level. ENVIRONMENTAL POLLUTION[J]. 2021, 287: http://dx.doi.org/10.1016/j.envpol.2021.117345.
[9] Sun, Yunxiang, Kakinen, Aleksandr, Wan, Xulin, Moriarty, Niamh, Hunt, Cameron P J, Li, Yuhuan, Andrikopoulos, Nicholas, Nandakumar, Aparna, Davis, Thomas P, Parish, Clare L, Song, Yang, Ke, Pu Chun, Ding, Feng. Spontaneous formation of beta-sheet nano-barrels during the early aggregation of Alzheimer's amyloid beta. NANO TODAY[J]. 2021, 38: [10] Lu Peng, Yawen Wang, Bingwei Yang, Qi Qin, Erqun Song, Yang Song. Polychlorinated biphenyl quinone regulates MLKL phosphorylation that stimulates exosome biogenesis and secretion via a short negative feedback loop. Environmental Pollution. 2021, 274: [11] Tao, Xiaoqi, Wan, Xulin, Wu, Di, Song, Erqun, Song, Yang. A tandem activation of NLRP3 inflammasome induced by copper oxide nanoparticles and dissolved copper ion in J774A.1 macrophage. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 411: http://dx.doi.org/10.1016/j.jhazmat.2021.125134.
[12] Chen, Qifang, Ma, Xianbin, Xie, Li, Chen, Wenjie, Xu, Zhigang, Song, Erqun, Zhu, Xiaokang, Song, Yang. Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment. NANOSCALE[J]. 2021, 13(9): 4855-4870, https://www.webofscience.com/wos/woscc/full-record/WOS:000628024200013.
[13] Wang, Yuting, Xu, Lei, Peng, Lu, Fang, Changyu, Qin, Qi, Lv, Xuying, Liu, Zixuan, Yang, Bingwei, Song, Erqun, Song, Yang. Polybrominated diphenyl ethers quinone-induced intracellular protein oxidative damage triggers ubiquitin-proteasome and autophagy-lysosomal system activation in LO2 cells. CHEMOSPHERE[J]. 2021, 275: http://dx.doi.org/10.1016/j.chemosphere.2021.130034.
[14] Zhang, Lihui, Wei, Wei, Liu, Zixuan, Liu, Xuting, Song, Erqun, Song, Yang. Dual effects of fibrinogen decoration on the tuning of silica nanoparticles-induced autophagic response: The implication of sedimentation and internalization. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 408: http://dx.doi.org/10.1016/j.jhazmat.2020.124467.
[15] Liu, Zixuan, Zhu, Qiushuang, Song, Erqun, Song, Yang. Characterization of blood protein adsorption on PM2.5 and its implications on cellular uptake and cytotoxicity of PM2.5. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 414: http://dx.doi.org/10.1016/j.jhazmat.2021.125499.
[16] Liu, Xuting, Lu, Bin, Fu, Juanli, Zhu, Xiaokang, Song, Erqun, Song, Yang. Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells. JOURNAL OF HAZARDOUS MATERIALS[J]. 2021, 404: http://dx.doi.org/10.1016/j.jhazmat.2020.124050.
[17] Wenjing Dong, Erqun Song, Yang Song. Co-administration of lipopolysaccharide and d-galactosamine induces genotoxicity in mouse liver. SCIENTIFIC REPORTS[J]. 2021, 11(1): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7814041/.
[18] Zhang, Changping, Liu, Zixuan, Zhang, Yuhao, Ma, Liang, Song, Erqun, Song, Yang. "Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis. CELL DEATH & DISEASE[J]. 2020, 11(3): http://dx.doi.org/10.1038/s41419-020-2384-5.
[19] Tan, Ya, Zhu, Xiangyu, Wu, Di, Song, Erqun, Song, Yang. Compromised Autophagic Effect of Polystyrene Nanoplastics Mediated by Protein Corona Was Recovered after Lysosomal Degradation of Corona. ENVIRONMENTAL SCIENCE & TECHNOLOGY[J]. 2020, 54(18): 11485-11493, https://www.webofscience.com/wos/woscc/full-record/WOS:000572834700051.
[20] Liu, Jing, Yang, Bingwei, Wang, Yuting, Wu, Yunjie, Fan, Bailing, Zhu, Sixi, Song, Erqun, Song, Yang. Polychlorinated biphenyl quinone promotes macrophage polarization to CD163(+) cells through Nrf2 signaling pathway. ENVIRONMENTAL POLLUTION[J]. 2020, 257: http://dx.doi.org/10.1016/j.envpol.2019.113587.
[21] Yang, Bingwei, Qin, Qi, Xu, Lei, Lv, Xuying, Liu, Zixuan, Song, Erqun, Song, Yang. Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2020, 33(6): 1497-1507, https://www.webofscience.com/wos/woscc/full-record/WOS:000541877700023.
[22] Liu, Zixuan, Lv, Xuying, Xu, Lei, Liu, Xuting, Zhu, Xiangyu, Song, Erqun, Song, Yang. Zinc oxide nanoparticles effectively regulate autophagic cell death by activating autophagosome formation and interfering with their maturation. PARTICLE AND FIBRE TOXICOLOGY[J]. 2020, 17(1): http://dx.doi.org/10.1186/s12989-020-00379-7.
[23] Song Yang. Synthesis and anti-inflammatory effect of novel emodin derivatives bearing azole moieties. Archiv der Pharmazie. 2020, [24] Liu, Zixuan, Lv, Xuying, Song, Erqun, Song, Yang. Fostered Nrf2 expression antagonizes iron overload and glutathione depletion to promote resistance of neuron-like cells to ferroptosis. TOXICOLOGY AND APPLIED PHARMACOLOGY[J]. 2020, 407: http://dx.doi.org/10.1016/j.taap.2020.115241.
[25] Liu, Jing, Tan, Ya, Song, Erqun, Song, Yang. A Critical Review of Polychlorinated Biphenyls Metabolism, Metabolites, and Their Correlation with Oxidative Stress. CHEMICAL RESEARCH IN TOXICOLOGYnull. 2020, 33(8): 2022-2042, https://www.webofscience.com/wos/woscc/full-record/WOS:000562983300002.
[26] Liu, Jing, Tan, Ya, Yang, Bingwei, Wu, Yunjie, Fan, Bailing, Zhu, Sixi, Song, Erqun, Song, Yang. Polychlorinated biphenyl quinone induces hepatocytes iron overload through up-regulating hepcidin expression. ENVIRONMENT INTERNATIONAL[J]. 2020, 139: http://dx.doi.org/10.1016/j.envint.2020.105701.
[27] Yang, Bingwei, Wang, Yawen, Qjn, Qi, Xia, Xiaomin, Liu, Zixuan, Song, Erqun, Song, Yang. Polychlorinated Biphenyl Quinone Promotes Macrophage-Derived Foam Cell Formation. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(12): 2422-2432, https://www.webofscience.com/wos/woscc/full-record/WOS:000503330600005.
[28] Shi, Qiong, Wang, Yawen, Dong, Wenjing, Song, Erqun, Song, Yang. Polychlorinated biphenyl quinone-induced signaling transition from autophagy to apoptosis is regulated by HMGB1 and p53 in human hepatoma HepG2 cells. TOXICOLOGY LETTERS[J]. 2019, 306: 25-34, http://dx.doi.org/10.1016/j.toxlet.2019.02.002.
[29] Dong, Wenjing, Zhu, Qiushuang, Yang, Bingwei, Qin, Qi, Wang, Yawen, Xia, Xiaomin, Zhu, Xiaokang, Liu, Zixuan, Song, Erqun, Song, Yang. Polychlorinated Biphenyl Quinone Induces Caspase 1-Mediated Pyroptosis through Induction of Pro-inflammatory HMGB1-TLR4-NLRP3-GSDMD Signal Axis. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(6): 1051-1057, https://www.webofscience.com/wos/woscc/full-record/WOS:000472241800016.
[30] Dong, Wenjing, Tan, Ya, Qin, Qi, Yang, Bingwei, Zhu, Qiushuang, Xu, Lei, Liu, Zixuan, Song, Erqun, Song, Yang. Polybrominated Diphenyl Ethers Quinone Induces NCOA4-Mediated Ferritinophagy through Selectively Autophagic Degradation of Ferritin. CHEMICAL RESEARCH IN TOXICOLOGY[J]. 2019, 32(12): 2509-2516.
Patents granted:
1. Song Yang, Song Erqun, Li Xiaoyao, Cyclophosphamide derivatives and their use as antitumor drugs, Patent No. ZL201110424586.0, China
2. Song Yang, Song Erqun, Li Xiaoyao, An acetaminophen-phosphonazepine antitumor drug and its preparation method, Chinese Patent, Patent No. ZL201110434041.8
4. Song Erqun, Song Yang, Magnetically encoded fluorescent-magnetic multifunctional nanocomplex and its preparation method, Chinese Patent, Patent No. ZL201310344477.7
5. Song Yang, Xia Xiaomin, Fu Juanli, Su Chuanyang, Shi Qiong, Song Xiufang, Song Erqun, New uses of neohesperidin dihydrochadion, Chinese Patent, Patent No. ZL201510426616.X
6 Song Erqun, Song Yang, Yu Mengqun, Preparation method of ticoranine functionalized nanogold and its products and applications, Chinese Patent, Patent No. ZL201610488526.8
Contact information:
E-mail address: yangsong@rcees.ac.cn
Address for correspondence: Ecological and Environmental Research Center, Chinese Academy of Sciences, 18 Shuangqing Road, Haidian District, Beijing, China
